Research suggests new way to treat inflammatory gut disease and prevent...
A new study explains how a widely used drug is effective against inflammatory bowel disease and rejection of bone marrow transplants, while suggesting another way to address both health issues.
View ArticleSmoking may cause inflammatory bowel disease
A new study shows a direct effect of cigarette smoke on intestinal inflammation for the first time. Researchers in South Korea report that exposing mice to cigarette smoke results in colitis, an...
View ArticleBioactive lipids and rheumatoid arthritis
Sphingolipids – long-chain fatty acid molecules found in cell membranes – are broken down by sphingomyelinase enzymes into bioactive products such as ceramide. Growing evidence suggests roles for...
View ArticleNew insights into the release of molecules involved in inflammatory diseases
In a recent study published in Cell Reports, a research team led by Colin Adrain, from the Instituto Gulbenkian de Ciência (IGC, Portugal), discovered the mechanism that controls the release of...
View ArticleResearchers produce the first draft cell atlas of the small intestine
The lining or epithelium of the gut is one of the body's most diverse and dynamic tissues, an ecosystem of cells that acts as one of the body's main interfaces with the outside world. To better...
View ArticleResearchers report epidermal cell differentiation findings
To ensure the barrier function of the skin, mutual regulation of connections between epidermal cells and a receptor for growth factors is necessary. These findings can help to reduce the effects of...
View ArticleScientists unravel likely causes of blood vessel leakage in severe dengue
A protein secreted by cells infected with dengue virus can cause dangerous leakage of fluid from blood vessels, and new research published in PLOS Pathogens supports a primary underlying mechanism:...
View ArticleNewly found immune defence could pave way to treat allergies
Scientists have made a fundamental discovery about how our body's immune system clears harmful infections.
View ArticleLung cancer triggers pulmonary hypertension
Shortness of breath and respiratory distress often increase the suffering of advanced-stage lung cancer patients. These symptoms can be triggered by pulmonary hypertension, as scientists at the Max...
View ArticleMaintaining sufficient vitamin D levels may help to prevent rheumatoid arthritis
Maintaining sufficient vitamin D levels may help to prevent the onset of inflammatory diseases like rheumatoid arthritis, research led by the University of Birmingham has discovered.
View ArticleDiscovery of potent parasite protein may lead to new therapeutic options for...
A single protein from a worm parasite may one day offer new therapeutic options for treating inflammatory bowel diseases like Crohn's or Ulcerative Colitis, that avoid the potentially serious side...
View ArticleResearchers uncover link between immune function and osteoarthritic pain and...
The immune system plays a pivotal role in the amount of pain and disease progression experienced by patients with osteoarthritis (OA), McMaster University researchers have found.
View ArticleStem cell-derived intestine model mimics innate immune responses
A stem cell-derived in vitro model displays key small intestine characteristics including innate immune responses, according to a study published November 29, 2017 in the open-access journal PLOS ONE...
View ArticleAn anti-aging protein could be targeted to rejuvenate immune cells
Anti-aging proteins have long been shown to protect against age-related diseases, such as cancer, neurodegeneration, and cardiovascular disease. A study by researchers at the Gladstone Institutes now...
View ArticleLineage tracing in the gut
Scientists are finding that they can understand organ function (and dysfunction in the case of disease) better if they know where the cells that make up these organs came from.
View ArticleWhat is inflammation and how does it cause disease?
Inflammation has a major impact on our health and quality of life. It's the trigger behind many chronic diseases and a growing burden affecting health care across the globe. But what is inflammation?...
View ArticleProtein's role in lupus development
Northwestern Medicine scientists have demonstrated that the loss of a protein called Bim in macrophages—a type of immune cell—leads to the development of lupus-like disease in mice. The findings,...
View ArticleRole of transcriptional co-factor hints at possible inflammatory bowel...
Inflammatory bowel disease (IBD), including the two conditions ulcerative colitis and Crohn's disease, results in long-term inflammation of the gut and is associated with dysregulation of the immune...
View ArticleMarijuana may help HIV patients keep mental stamina longer
A chemical found in marijuana, known as tetrahydrocannabinol, or THC, has been found to potentially slow the process in which mental decline can occur in up to 50 percent of HIV patients, says a new...
View ArticleDysfunctional gene may be culprit in some Crohn's disease cases
This holiday season, millions of people will gather at airports ready to board planes for destinations around the world. Depending on the environment at their destination, their suitcases may be filled...
View ArticleSelective suppression of inflammation could deplete HIV and control HIV...
A class of anti-inflammatory drugs already FDA-approved for rheumatoid arthritis could "purge" the reservoir of infected immune cells in people infected by HIV, according to new research.
View ArticleMultiple sclerosis—cholesterol crystals prevent regeneration in central...
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, in which the body's own immune cells attack the fatty, insulating myelin sheath surrounding nerve fibers. The...
View ArticleGene/cell connection provides new insight into how our gut microbiome stays...
Paneth cells are like an internal antibiotic that eliminates unwanted microbes that make their way into our small intestine and helps us maintain a healthy gut microbiome.
View ArticleScientists identify immune cells that keep gut fungi under control
Immune cells that process food and bacterial antigens in the intestines control the intestinal population of fungi, according to a new study from Weill Cornell Medicine scientists. Defects in the...
View ArticleFast food makes the immune system more aggressive in the long term
The immune system reacts similarly to a high fat and high calorie diet as to a bacterial infection. This is shown by a recent study led by the University of Bonn. Particularly disturbing: Unhealthy...
View ArticlePancreatic tumors may require a one-two-three punch
One of the many difficult things about pancreatic cancer is that tumors are resistant to most treatments because of their unique density and cell composition. However, in a new Wilmot Cancer Institute...
View ArticleOxysterols guide gut immune cells and are involved in inflammatory bowel disease
Researchers at Karolinska Institutet in Sweden report that cholesterol metabolites cause specific immune cells in the large intestine to move, which lies behind the formation of the immune system's...
View ArticleCellular mechanism for severe viral hepatitis identified
KAIST medical scientists identified a cellular mechanism causing inflammatory changes in regulatory T cells that can lead to severe viral hepatitis. Research on this mechanism will help further...
View ArticleImmunologist heralds the dawn of a new health revolution
A brave new world of immune system therapies – harnessing the body's own defences – could help treat all kinds of different illnesses, according to one of the UK's leading immunologists.
View ArticleThe biological clock as an ally in the fight against inflammatory disease
What if the symptoms and seriousness of certain inflammatory diseases were linked to time of day? Researchers from Inserm, Institut Pasteur de Lille and Université de Lille have been working on this...
View Article
