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Reactive oxygen species—fueling or putting the brakes on inflammation?

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Reactive oxygen species (ROS) such as peroxides and superoxides are important signalling molecules in an organism's regulation of metabolism and inflammation. Accumulation of ROS have been linked to neurodegeneration and cancer. Researchers at Umeå University and Hospital of Halland in Sweden now reveal an unexpected function of ROS. They dampen a key inflammatory process and weaken the immune system´s ability to combat pathogens such as those that cause pneumonia. The findings are published in the July 2016 issue of the Cell Press Journal Immunity.

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